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观察鼻咽癌（NPC）后程加速超分割放疗和辅助化疗的急性反应及近期疗效。方法 按随机方法将26例早期（Ⅰ～Ⅱ期）NPC分为常规分割放疗组及后程加速超分割放疗组，54例晚期（Ⅲ～Ⅳ期）NPC分为常规分割放疗组，后程加速超分割放疗组及后程加速超分割放疗辅助化疗组。结果后程加速超分割放疗辅助化疗组原发肿瘤肉眼消失剂量明显低于未加化疗的其它二组（P＜0．05），各组急性反应程度无明显差异（P＞0．05），而后程加速超分割放疗（包括辅助化疗组）组治疗结束时肿物残存率与常规放疗组相比有下降趋势。结论后程加速超分割放疗和辅助化疗可能为NPC治疗的一种较好的方法，值得进一步研究。
To observe the acute response and short-term efficacy of late-course hyperfractionated radiotherapy and adjuvant chemotherapy for nasopharyngeal carcinoma (NPC). Methods Twenty-six early (I-II) NPCs were randomly divided into conventional segmented radiotherapy group and late-course accelerated hyperfractionated radiotherapy group. Fifty-four advanced stage (III-IV) NPCs were divided into conventional fractionated radiotherapy groups. Hyperfractionated radiotherapy group and late course accelerated hyperfractionated radiotherapy adjuvant chemotherapy group. RESULTS: The disappearance doses of primary tumors in the late-course accelerated hyperfractionated radiotherapy-assisted chemotherapy group were significantly lower than those in the other two groups without chemotherapy (P<0.05). There was no significant difference in the degree of acute reaction among the groups (P>0.05). However, the survival rate of tumors at the end of treatment in the hyperacute hyperfractionation radiotherapy (including adjuvant chemotherapy group) group was decreased compared with the conventional radiotherapy group. Conclusions Accelerated hyperfractionation radiotherapy and adjuvant chemotherapy may be a better method for NPC treatment and deserve further study.