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目的:考察碘伏(络合碘)消毒液的动物亚急性毒性试验,了解其安全性。方法:采用动物实验和生化检验法进行其亚急性毒性评价。结果:给药期间,试验大鼠高、中、低剂量组体重同阴性对照组比较(P>0.05);试验动物血常规和白细胞分类及生化检查结果均在正常范围内,与阴性对照组相比(P>0.05);各剂量组大鼠脏器重量及脏/体比结果与阴性对照组相比(P>0.05);病理组织检查,试验动物各脏器均未见明显病理改变。结论:亚急性经口毒性试验结果表明,给予剂量为1000,500,250mg·kg~(-1)体重,碘伏对大鼠的体重、病理组织学、血液及生化学等指标无显著影响,未发现明显毒性作用。
Objective: To investigate the subacute toxicity test of iodophor (complex iodine) disinfectant to understand its safety. Methods: Subacute toxicity was evaluated by animal experiments and biochemical tests. Results: During the administration, body weight of high, medium and low dose groups were compared with that of negative control group (P> 0.05); the blood routine and leukocyte classification and biochemical test results of experimental animals were within the normal range, (P> 0.05). Compared with the negative control group (P> 0.05), the organ weight and the visceral / body ratio of rats in each dose group showed no significant pathological changes in the pathological examination and test organs. CONCLUSIONS: The results of subacute oral toxicity test showed that iodophor had no significant effect on the body weight, histopathology, blood and biochemical indexes of rats at doses of 1000, 500 and 250 mg · kg -1 Significant toxic effects were found.