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[目的]探讨胰岛素样生长因子-2(IGF-2),瘦素(leptin),巨噬细胞移动抑制因子(MIF)和泌乳素(PRL)4种血清标志物对卵巢癌的诊断价值。[方法]应用液相芯片技术检测25例卵巢癌患者和90例健康人群血清中IGF-2、leptin、MIF和PRL的水平。[结果]IGF-2、Leptin以及MIF3种检测指标在卵巢癌手术前与体检人群组之间的差异有统计学意义(P﹤0.01,P﹤0.05,P﹤0.01)。4种检测指标的ROC曲线下面积的检验结果显示IGF-2和Lep-tin有诊断价值。[结论]检测IGF-2和leptin对卵巢癌的诊断有一定的诊断价值,联合检测诊断价值更高。
[Objective] To investigate the diagnostic value of serum markers of insulin-like growth factor-2 (IGF-2), leptin, macrophage migration inhibitory factor (MIF) and prolactin (PRL) in ovarian cancer. [Method] The serum levels of IGF-2, leptin, MIF and PRL in serum of 25 patients with ovarian cancer and 90 healthy people were detected by liquid chromatography. [Results] There were significant differences in the detection indexes of IGF-2, Leptin and MIF before ovarian cancer and physical examination population (P <0.01, P <0.05, P <0.01). The test results of the area under the ROC curve of 4 kinds of test indexes showed that IGF-2 and Lep-tin had diagnostic value. [Conclusion] The detection of IGF-2 and leptin has some diagnostic value in the diagnosis of ovarian cancer, and the value of combined detection is higher.