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目的探讨软骨母细胞瘤的临床、影像学和病理形态学特征,明确诊断要点。方法收集9例有完整临床资料的软骨母细胞瘤病例,对其临床、影像学和病理资料作回顾性分析。结果 9例患者中男性5例,女性4例,发病年龄14～33岁,平均年龄19.7岁,>20岁者2例。最常见的发病部位是股骨,主要症状是轻度局部疼痛。影像学上9例均为囊状溶骨性改变,术前只有1例确诊。镜下9例均能观察到软骨母细胞瘤的3种组成成分:软骨母细胞、破骨细胞样巨细胞和软骨基质。9例中7例软骨母细胞S-100(+)。结论软骨母细胞瘤的诊断需结合年龄、部位、影像学特点,并重点把握住软骨母细胞瘤的3种镜下成分。
Objective To investigate the clinical, radiological and pathomorphological features of chondroblastoma and to make clear the main points of diagnosis. Methods Nine cases of chondroblastoma with complete clinical data were collected and analyzed retrospectively for clinical, radiological and pathological data. Results Among the 9 patients, 5 were males and 4 were females. The age of onset was from 14 to 33 years, with an average age of 19.7 years and 2 years> 20 years. The most common site of disease is the femur, the main symptom is mild local pain. All 9 cases were cystic osteolytic changes in imaging. Only 1 case was confirmed before operation. Three components of chondroblastoma were observed in all 9 cases: chondroblast, osteoclast-like giant cells and cartilage matrix. Seven cases of chondroblast S-100 (+) in 9 cases. Conclusion The diagnosis of chondroblastoma need to be combined with age, location, imaging features and focus on the three components of chondroblastoma.