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目的：探讨遗传因素造成扬中市胃癌家族聚集性的作用方式与强度。方法：利用全新设计的双Ｙ核心家系调查方法，对扬中市４４８个胃癌核心家系和４３７个对照家系，共５２４２人进行了分离比和遗传度研究。结果：祛除先证者后，扬中市胃癌家系的调整分离比为 ０.０１４３，表明同胞中胃癌发病率远低于单基因遗传病的 ０.２５，符合多基因遗传方式；一级亲属中胃癌的调整遗传度为 ２３．８％，男性（２７.８％）明显高于女性（１７．１％）。结论：扬中市胃癌呈明显家族聚集性的原因中，遗传易感性因素作用约占 １／４，指出阐明遗传易感基因与环境因素交互作用的研究对胃癌病因预防至关重要。
Objective: To explore the mode of action and intensity of genetic factors that cause clustering of gastric cancer in Yangzhong City. Methods: Using a newly designed double-Y core family survey method, the separation ratio and heritability of 524 gastric core families and 437 control families in Yangzhong City were studied. Results: After eliminating the proband, the adjusted ratio of gastric cancer in Yangzhong City was 0.0143, indicating that the incidence of gastric cancer in siblings was far lower than that of single genetic disease 0.25, which accorded with multi-gene inheritance; gastric cancer in first-degree relatives The adjusted heritability was 23.8%, male (27.8%) was significantly higher than female (17.1%). Conclusion: Among the causes of the familial clustering of gastric cancer in Yangzhong City, the genetic susceptibility factor accounted for approximately 1/4 of the factors. It is pointed out that the study of the interaction between genetic susceptibility genes and environmental factors is very important for the prevention of gastric cancer.