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雄性日本大耳白兔、体重约2kg。随机分为实验组和对照组,每组10只。对照组喂普通兔饲料,实验组再加喂胆固醇0.7g/日,共12周。实验结束时,禁食12小时后颈动脉取血,测血清apo AI、apo B、HDLC、(β-VLDL+LDL)-C和EPO含量。实验兔血清apo AI水平无明显变化,但HDL-C/apo AI值升高,表明其HDL已发生变化。实验兔apo B明显升高,apo AI/apo B值明显降低,HDL-TC明显隆低,(β-VLDL+LDL)-C/TC明显升高,表明实验性高胆固醇血症时,血浆胆固醇主要存在于致
Male Japanese white rabbits, weighing about 2kg. Randomly divided into experimental group and control group, 10 in each group. Control group fed normal rabbit feed, experimental group plus cholesterol 0.7g / day, a total of 12 weeks. At the end of the experiment, carotid blood was taken 12 hours after fasting, and serum apo AI, apo B, HDLC, (β-VLDL + LDL) -C and EPO were measured. Serum apo AI levels in experimental rabbits did not change significantly, but HDL-C / apo AI increased, indicating that the HDL has changed. The level of apo B and Bcl-2 in experimental rabbits increased significantly, the apo AI / apo B values decreased significantly, HDL-TC was significantly lower and β-VLDL + LDL-C / TC significantly increased, indicating that plasma cholesterol Mainly in the cause