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目的 评价吡柔比星经动脉灌注化疗治疗恶性性肿瘤的临床疗效及毒副反应。材料与方法 43例明确诊断的恶性肿瘤 (肝癌 30例 ,肺癌 13例 ) ,应用以 THP为主的联合化疗方案经动脉插管灌注化疗 ,化疗前后查心电图 ,肝肾功能 ,血常规 ,影象学检查。结果 肿瘤治疗总有效率为 5 1.16 %。毒副反应为 ～ 度 ,8例于化疗后第一周出现一过性心电图改变 ,占 18.6 0 % ,7例外周血白细胞数降低 ,占 16 .2 8% ,13例出现胃肠道反应 ,占 30 .2 3% ,7例肝功能损害 ,占 16 .2 8%。结论 THP为主的联合化疗方案经动脉插管灌注化疗治疗恶性肿瘤是安全有效的。
Objective To evaluate the clinical efficacy and toxicity of pirarubicin transcatheter arterial infusion chemotherapy for malignant tumors. Materials and Methods Forty-three cases of definite malignant tumors (30 cases of liver cancer and 13 cases of lung cancer) were treated with arterial intubation chemotherapy with THP-based combination chemotherapy, electrocardiogram, liver and kidney function, blood routine, and image before and after chemotherapy. Learn to check. Results The total effective rate of tumor treatment was 51.16%. The toxicity was ~ degree, 8 cases had a transient electrocardiogram change in the first week after chemotherapy, accounting for 18.60%, 7 cases had a decrease in the number of white blood cells, accounting for 16.28%, and 13 cases had gastrointestinal reactions. Accounting for 30.23%, 7 cases had liver damage, accounting for 16.28%. Conclusions THP-based combined chemotherapy regimens are safe and effective for transcatheter arterial infusion chemotherapy for malignant tumors.