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抗病毒口服液是由连翅、知母、板蓝根等九味中药制成的纯中药制组成,用于治疗病毒性感冒。处方 中的连翘具有清热解毒、宣散风热、消痛散结的功能,具广谱抗菌作用。原质量标准中是采用薄层扫描法测定连翘中的有效成份连翘甙的含量,但是操作极繁琐,而且标准品与样品斑点均不明显,重复性差。有报道用HPLC法测定抗病毒口服液中连翘甙的含量,但采用的柱填充剂为氨基键合相,测定结果相对偏低。本文吸取报道的长处,结合实验研究,采用反相高效液相色谱法测定该制剂中连翘甙含量,结果满意,方法简便,重现性好,回收率99.2％,为该制剂的质量控制提供了可行的方法。
Antiviral oral liquid is composed of pure Chinese medicine made from nine herbs, including winged peony root, Anemarrhena and Radix isatidis. It is used to treat viral influenza. Forsythia in prescriptions has the functions of clearing heat, detoxifying, dispelling wind and heat, and dispelling pain and disintegrating. It has a broad-spectrum antibacterial effect. In the original quality standard, the content of forsythia quinone in the effective component of Forsythia suspensa was determined by a thin-layer scanning method, but the operation was very cumbersome, and the spots of the standard product and the sample were not obvious, and the repeatability was poor. It has been reported that the content of forsythia in the antiviral oral solution was measured by HPLC, but the column packing used was an amino-bonded phase, and the measurement result was relatively low. This article took advantage of the report, combined with experimental research, using RP-HPLC determination of forsythia content in the preparation, the results were satisfactory, the method is simple, reproducible, the recovery rate of 99.2%, for the quality control of the preparation The feasible method.