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本文采用Ｄｏｔ－ＩＧＳ法对２０６例有上消化道症状患儿及８０例健康儿童进行血清Ｈｐ抗体测定。结果表明，上消化道症状组血清Ｈｐ抗体阳性率（３５．４％）明显高于健康对照组（１３．８％）；血清Ｈｐ抗体阳性率与性别无关，而随年龄增大逐渐增高。病程１个月以上患儿血清Ｈｐ抗体阳性率（５０．０％）明显高于～１个月病程组（１９．４％）及≤２周病程组（１１．３％）。血清Ｈｐ抗体阳性患儿其父母有慢性胃炎或消化道溃疡病史所占比例（７５％）明显高于Ｈｐ抗体阴性患儿（１２．４％）。提示Ｈｐ感染为小儿上消化道疾病主要原因；Ｈｐ感染随年龄增大而增高，并有家庭聚集现象。判断血清Ｈｐ抗体检查结果，还需考虑患儿病程。
In this paper, Dot-IGS method for 206 cases of upper gastrointestinal symptoms in children and 80 healthy children serum Hp antibody. The results showed that the positive rate of serum Hp antibody in upper gastrointestinal symptoms group was significantly higher than that in healthy control group (35.4% vs 13.8%). The positive rate of serum Hp antibody was not related to gender, but increased with age. The positive rate of Hp antibody (50.0%) in children with the course of more than 1 month was significantly higher than that in ~ 1 month course (19.4%) and ≤2 weeks course group (11.3%). Serum Hp antibody-positive children whose parents had a history of chronic gastritis or peptic ulcer (75%) were significantly higher than Hp antibody-negative children (12.4%). Hp infection prompted the main cause of upper gastrointestinal diseases in children; Hp infection increased with age, and the phenomenon of family aggregation. Judgment of serum Hp antibody test results, but also consider the child’s course.