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目的探讨小剂量倍美力补充治疗女性更年期综合征的治疗效果。方法将63例出现典型更年期综合征的妇女随机分为两组,倍美力组42例,给予倍美力+醋酸甲羟孕酮片治疗;对照组21例,给予中成药消遥丸+中成药六味地黄丸治疗。比较两组妇女更年期症状的改善、性激素的改变、血脂的变化、用药后安全性监测指标的变化。结果两组的更年期症状经治疗后均有一定疗效,倍美力组尤为明显,两组之间差异有统计学意义(P<0.05);两组用药前促卵泡生成素(FSH)、雌激素(E2)水平差异无统计学意义,治疗6个月及1年时差异有统计学意义(P<0.01);A组和B组用药前及用药后第5周期所有对象的血脂的变化,两组与用药前比较,差异无统计学意义(P>0.05);子宫内膜厚度的变化,两组用药前后,差异均无统计学意义(P>0.05);A组撤退性阴道出血为35例(83.3%),对照组未见典型的撤退性阴道出血;两组均有部分观察对象有轻微乳房胀痛,用药前及第5周期体重均无显著变化(P>0.05),用药后均未见血压明显改变;对肝、肾功能均无影响(P>0.05)。结论倍美力改善潮热等更年期综合征的疗效优于中成药消遥丸。
Objective To investigate the therapeutic effect of low dose Betamel supplementation on female climacteric syndrome. Methods Sixty-three women with typical menopausal syndrome were randomly divided into two groups. Forty-eight patients were treated with bemetrine and metoprolol acetate. In the control group, 21 patients were treated with Chinese traditional medicine, Chinese medicine Liu Wei Di Huang Wan treatment. The improvement of menopausal symptoms, the change of sex hormones, the change of blood lipids and the change of safety monitoring indexes after treatment were compared between the two groups. Results The climacteric symptoms in both groups had certain curative effect after treatment, especially in Beimei Li group, with significant difference between the two groups (P <0.05). The levels of follicle stimulating hormone (FSH), estrogen (E2), there was no significant difference between the two groups (P <0.01). The changes of blood lipids in all the subjects before and after the treatment of group A and group B There was no significant difference between the two groups before and after treatment (P> 0.05). There was no significant difference between the two groups before and after treatment (P> 0.05). In group A, there were 35 cases of withdrawal vaginal bleeding (83.3%). There was no typical withdrawal vaginal bleeding in the control group. Some patients in both groups had minor breast tenderness and had no significant changes in body weight before and during the fifth week (P> 0.05) See significant changes in blood pressure; no effect on liver and kidney function (P> 0.05). Conclusion The efficacy of MEBO in improving hot flashes and other climacteric syndromes is better than that of Chinese traditional medicine,