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近年来由于生活质量提高,饮食中多富含蛋白质及脂类,其过度可引起人体血脂水平大幅度升高,导致高脂血症,严重时可引发动脉粥样硬化等一系列心血管疾病。他汀类药物可以阻碍胆固醇生成,降低血清胆固醇含量,还可以抑制肝脏合成载脂蛋白以降低脂蛋白的量。而洛伐他汀作为他汀类药物的代表,调脂作用明显,在临床中应用较为广泛。因其应用较多,临床上对其的相关研究也较为广泛。目前对于血脂异常的疾病通常首选他汀药物进行治疗,他汀类药物调脂作用效果显
In recent years, due to the improvement of quality of life, the diet is rich in protein and lipids, which can cause excessive increase of blood lipid level, leading to hyperlipidemia and serious cardiovascular diseases such as atherosclerosis. Statins can block cholesterol production, lower serum cholesterol levels, but also can inhibit liver synthesis of apolipoprotein to reduce the amount of lipoprotein. Lovastatin, as the representative of statins, has obvious lipid regulating effect and is widely used in clinical practice. Because of its more application, its clinical research is also more extensive. The current treatment of dyslipidemia is often the first choice of statin therapy, statin lipid-lowering effect was significantly