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目的探讨缺血性脑血管病 (ICVD)患者血脂蛋白 (a) [LP(a) ]和D 二聚体水平的变化及其临床意义。方法测定86例ICVD患者血LP(a)和D 二聚体水平 ,并与 2 1例健康对照组比较。结果脑血栓形成 (CI)急性期和短暂性脑缺血发作 (TIA)患者D 二聚体、LP(a)的含量均明显高于健康对照组 (P <0 .0 5或P <0 .0 1)。TIA伴有梗死灶者血D 二聚体、LP(a)的含量均高于无梗死灶者 (P <0 .0 5 )。结论ICVD患者血D 二聚体、LP(a)水平升高 ,这与体内血液凝固性增强和高发血栓形成有关。测定血D 二聚体和LP(a)水平对ICVD病情预测和辅助诊断具有重要意义。
Objective To investigate the changes of serum lipoprotein (a) [LP (a)] and D dimer in patients with ischemic cerebrovascular disease (ICVD) and their clinical significance. Methods The levels of LP (a) and D dimer in 86 patients with ICVD were measured and compared with 21 healthy controls. Results The levels of D dimer and LP (a) in acute cerebral infarction (CI) and transient ischemic attack (TIA) patients were significantly higher than those in healthy controls (P <0.05 or P <0.05). 0 1). TIA with infarction in blood D dimer, LP (a) were higher than those without infarction (P <0.05). Conclusions The level of D-dimer and LP (a) in blood of patients with ICVD is increased, which is related to the enhancement of blood coagulation and thrombosis. Determination of blood D dimer and LP (a) levels of ICVD disease prediction and diagnosis is of great significance.