论文部分内容阅读
蛛网膜下腔出血(SAH)后约有40％～80％的患者出现脑血管痉挛(CVS),患者可因CVS导致脑缺血而出现意识障碍、神经功能缺失,严重者可发生脑梗死与软化,甚至导致死亡。Zerres曾说过:“动脉瘤的手术治疗已为神经外科医师较热练地掌握,而CVS却成为神经外科治疗动脉瘤的最大挑战。” 1 近年来,有关CVS的研究较多,最初,人们常针对血液和脑脊液中的血球碎片、红血球蛋白降解产物、血红蛋白、铁离子以及血氧自由基等进行研究,已发现三大类包括16种以上的物质可使血管平滑肌产生异常收缩。如:氧合血红蛋白(oxyHb),5—羟色胺(5—HT)、
Cerebral vasospasm (CVS) occurs in about 40% to 80% of patients after subarachnoid hemorrhage (SAH). Patients may experience disturbance of consciousness due to cerebral ischemia caused by CVS, and may have neurological deficits. In severe cases, cerebral infarction may occur Soften, and even cause death. Zerres once said: “Surgical treatment of aneurysms has become more neurotic for neurosurgeons and CVS has become the biggest challenge for neurosurgery in the treatment of aneurysms.” 1 In recent years there has been a great deal of research on CVS, and initially people Often for the blood and cerebrospinal fluid in the blood cells, erythrocyte degradation products, hemoglobin, iron ions and blood oxygen free radicals and other studies have been found in three categories, including more than 16 substances can make abnormal vascular smooth muscle contraction. Such as: oxyHb, 5-HT,