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早在60年代初,继法国学者Lejeune等发现人G-三体综合征开创了医学细胞遗传学这一新领域之后,两个美国医生又在慢性骨髓样白血病(CML)患者的细胞中发现了所谓的费城染色体(Ph_1染色体)。这一新的发现,曾哄动一时,使得许多细胞遗传学家和肿瘤专家试图从染色体异常来探讨肿瘤发生的原因。不幸的是,他们都一时难以获得预期的结果。不过,正如分子生物学家以为癌症与基因变异有关一样,大多数细胞遗传学家一直以为癌症与染色体异常有关,
Back in the early 1960s, following the discovery by the French scholar Lejeune et al of human G-trisomy syndrome of a new area of medical cytogenetics, two American doctors found in the cells of patients with chronic myeloid leukemia (CML) The so-called Philadelphia chromosome (Ph_1 chromosome). This new discovery, which has been furiously for a while, has led many cytogenetics and oncologists trying to explore the causes of tumors from chromosomal abnormalities. Unfortunately, they are hard-pressed to achieve the desired result. However, just as molecular biologists think cancer is related to genetic variation, most cytogenetics have always believed that cancer is associated with chromosomal abnormalities,