论文部分内容阅读
在无血清抗体时肯定可以发生吞噬现象.这种“非免疫性”或“非特异性”吞噬现象已见于多种细菌,唾液酸酶处理的红细胞,各种颗粒如酵母多糖、炭粒、石棉.这种识别作用是由颗粒表面的哪些特性及吞噬细胞表面的哪些因子来介导的这个问题,迄今尚无满意的解答.早年推测,颗粒表面的净电荷或疏水性决定了它是否被吞噬细胞识别.但难以得到试验证据.当然,某些非特异的表面性状(例如聚苯乙烯颗粒)可被吞噬细胞识别.但是,与生理学相关的颗粒必然涉及到一些更特殊的机制.
Phagocytosis can certainly occur with serum-free antibodies. This “non-immune” or “nonspecific” phagocytosis has been observed in a variety of bacteria, sialidase-treated erythrocytes, various particles such as zymosan, charcoal Grain, asbestos. This recognition is based on what characteristics of the particle surface and which factors on the phagocyte surface mediate this problem, so far there is no satisfactory answer. Early speculated that the particle surface of the net charge or hydrophobic determines it Whether it is recognized by phagocytes, but it is difficult to get experimental evidence.Of course, some non-specific surface properties (such as polystyrene particles) can be recognized by phagocytes.However, the physiological related particles must involve some more special mechanism.