论文部分内容阅读
目的 :探讨促炎细胞因子和抗炎细胞因子在急性胰腺炎 (AP)发病机制中的作用。方法 :应用 EL ISA法检测 4 8例病人血液中促炎细胞因子 (TNF 、IL- 1β、IL- 6、IL- 8)和抗炎细胞因子 (IL- 10、IL- 1ra)。结果 :AP病人血液中促炎细胞因子和抗炎细胞因子在早期持续显著升高 (与正常对照组相比 P<0 .0 5 ) ,其后逐渐下降 ,并与临床症状变化的时相一致。结论 :促炎细胞因子和抗炎细胞因子在急性胰腺炎的发生发展过程中可能均具有重要作用
Objective: To investigate the role of proinflammatory cytokines and anti-inflammatory cytokines in the pathogenesis of acute pancreatitis (AP). Methods: The blood levels of proinflammatory cytokines (TNF, IL-1β, IL-6, IL-8) and anti-inflammatory cytokines (IL-10, IL-1ra) in 48 patients were detected by ELISA. Results: The levels of proinflammatory cytokines and anti-inflammatory cytokines in the blood of AP patients were significantly increased at early stage (P <0.05 compared with the normal control group), and then decreased gradually, consistent with the time of clinical symptoms . Conclusion: Proinflammatory cytokines and anti-inflammatory cytokines may play an important role in the development of acute pancreatitis