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目的探讨阿奇霉素治疗支气管哮喘患儿的疗效及对外周血辅助性T淋巴细胞功能的影响。方法选取2011年2月—2015年1月江西省儿童医院收治的90例支气管哮喘患儿,采用随机数字表法将患儿分为研究组和对照组,各45例。对照组给予布地奈德、沙丁胺醇雾化吸入治疗,研究组在对照组的基础上加用阿奇霉素静注治疗,比较两组患儿临床疗效、治疗前后血清干扰素-γ(IFN-γ)、白介素-4(IL-4)水平及IFN-γ/IL-4。结果研究组总有效率为97.8%,高于对照组的82.2%,差异有统计学意义(P<0.05)。治疗前两组血清IFN-γ、IL-4水平及IFN-γ/IL-4比较,差异无统计学意义(P>0.05);治疗后研究组患儿IFN-γ水平、IFN-γ/IL-4高于对照组,IL-4水平低于对照组,差异有统计学意义(P<0.05)。结论阿奇霉素治疗支气管哮喘的临床疗效确切,可有效发挥免疫调节作用,改善患儿临床症状,促进患儿早日康复。
Objective To investigate the therapeutic effect of azithromycin on children with bronchial asthma and its effect on the function of helper T lymphocytes in peripheral blood. Methods From January 2011 to January 2015, 90 children with bronchial asthma admitted to Jiangxi Children’s Hospital were enrolled. Children were divided into study group and control group with 45 cases in each group by random number table. The control group was treated with budesonide and salbutamol inhalation. The study group was treated with intravenous injection of azithromycin on the basis of the control group. The clinical curative effect was compared between the two groups before and after treatment. The levels of serum IFN-γ (IFN-γ), interleukin -4 (IL-4) levels and IFN-γ / IL-4. Results The total effective rate of the study group was 97.8%, which was higher than that of the control group (82.2%), the difference was statistically significant (P <0.05). The levels of IFN-γ, IL-4 and IFN-γ / IL-4 in the two groups before treatment were not significantly different (P> 0.05) -4 higher than the control group, IL-4 levels lower than the control group, the difference was statistically significant (P <0.05). Conclusion The clinical efficacy of azithromycin in the treatment of bronchial asthma is exact, which can effectively exert immunomodulatory effects, improve the clinical symptoms and promote the early recovery of children.