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胃肠间质瘤(gastrointestinal stromal tumors,GIST)的发生与kit和PDGFR?α基因突变相关,有其独特的临床和病理特征。免疫组化的染色有助于GIST的诊断,而基因突变点的检测对临床应用伊马替尼和舒尼替尼治疗具有重要的指导意义。
The occurrence of gastrointestinal stromal tumors (GIST) is related to the mutation of kit and PDGFRα gene and has its unique clinical and pathological features. Immunohistochemical staining contributes to the diagnosis of GIST, and detection of gene mutation points is of great guiding significance for the clinical application of imatinib and sunitinib.