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目的研究影响狼疮肾炎进展的危险因素。方法回顾性分析58例狠疮性肾炎的病史、生化检查以及影像学资料。结果存在药物过敏和手术外伤史的狼疮性肾炎发生率分别为25.9%和22.4%,高血压组肾功能损害比无高血压者严重(P<0.01)。结论存在药敏和手术外伤史的肾病患者应警惕狼疮肾炎的可能性;高血压可加重狼疮肾炎损伤,应积极防控。
Objective To study the risk factors affecting the progression of lupus nephritis. Methods A retrospective analysis of 58 cases of lupus nephritis history, biochemical tests and imaging data. Results The incidence of lupus nephritis with history of drug allergy and surgical trauma was 25.9% and 22.4% respectively. The renal dysfunction in hypertension group was more serious than that without hypertension (P <0.01). Conclusion Patients with nephropathy with history of drug sensitivity and surgical trauma should be alert to the possibility of lupus nephritis. Hypertension may aggravate the injury of lupus nephritis and should be actively controlled.