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本文报告34例膀胱癌,13例其它恶性肿瘤,15例下尿路感染,21例正常人用放射免疫法测定血、尿β_2-微球蛋白(β_2-MG)及尿/血β_2-MG比值的结果,发现膀胱癌组尿β_2-MG值显著高于其它任何一组,其增高者(>240μg/L)占79%.尿β_2-MG及尿/血β_2-MG比值随肿瘤的分期、分级增加而增高.作者讨论了影响测定β_2-MG的因素和测定β_2-MG的临床意义,认为尿β_2-MG升高可能由于肿瘤细胞释放β_2-MG到尿里.测定尿β_2-MG对诊断膀胱癌或血尿的鉴别诊断有重要意义,也可能对术前估计肿瘤的恶性程度,术后监测肿瘤复发有一定意义
This article reports 34 cases of bladder cancer, 13 cases of other malignant tumors, 15 cases of lower urinary tract infection, 21 cases of normal people by radioimmunoassay measured blood and urine β_2-microglobulin (β_2-MG) and urinary / blood β_2-MG ratio The results showed that urinary β_2-MG in bladder cancer group was significantly higher than that in any other group (79%), and the ratio of urine β_2-MG and urine / blood β_2-MG increased with the stage of tumor, The authors discuss the clinical significance of the determination of β_2-MG and the determination of β_2-MG, that elevated urine β_2-MG may be due to tumor cells release β_2-MG into the urine. Determination of urinary β_2-MG on the diagnosis The differential diagnosis of bladder cancer or hematuria is of great significance, may also be preoperative estimate of the degree of malignancy of the tumor, postoperative monitoring of tumor recurrence has some significance