论文部分内容阅读
鉴于安妥明对高血脂Ⅱ_a型无效,且有不良副作用,作者用多种方法合成了110多种桂皮酸衍生物。经大鼠筛选试验表明,具有较高级对位烷氧取代的桂皮酸、α-甲基桂皮酸及其酯类所具有显著的降胆固醇和甘油三酯活性大于或等于安妥明。其构-效关系为:(1)烷氧基
Given that clofibrate is not effective against hyperlipidemia type II_a and has adverse side effects, the authors synthesized more than 110 cinnamic acid derivatives using a variety of methods. Rat screening tests showed that cinnamic acid, α-methyl cinnamic acid and its esters with higher para-position alkoxy substitution have significant cholesterol and triglyceride activity greater than or equal to clofibrate. The structure-effect relationship is: (1) alkoxy