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目的探讨不同时间高压氧(Hyperbaric Oxygen,HBO)治疗对一氧化碳中毒迟发脑病(Delayed encephalop-athy after acute carbon monoxide poisoning DEACMP)的影响。方法观察组132例中、重度急性一氧化碳中毒(ACOP)患者中毒后接受常规治疗的同时8h内进行HBO治疗,对照组118例中、重度患者在中毒后给予常规治疗,8h后进行HBO治疗,观察两组总治愈率及DEACMP发生率。结果观察组和对照组总治愈率、DEACMP发生率分别为98.5%、94.1%和6.1%、19.5%,观察组和对照组总治愈率比较无统计学意义,P>0.05;两组间DEACMP发生率比较有统计学意义,P<0.05。结论 8h内及时给予HBO治疗和8h后进行HBO治疗比较,DEACMP发生率明显降低,说明DEACMP的发生率与HBO治疗时机密切相关。
Objective To investigate the effects of Hyperbaric Oxygen (HBO) at different time on delayed-encephalop-athy after acute carbon monoxide poisoning (DEACMP). Methods In the observation group, 132 cases of moderate and severe acute carbon monoxide poisoning (ACOP) patients were treated with HBO after poisoning within 8 hours. HBO was given to 118 moderate and severe patients in the control group after poisoning, and HBO after 8 hours. The two groups of total cure rate and DEACMP incidence. Results The total cure rate and the rate of DEACMP in the observation and control groups were 98.5%, 94.1% and 6.1%, 19.5% respectively. There was no significant difference between the observation group and the control group (P> 0.05). DEACMP occurred between the two groups The rates were statistically significant, P <0.05. Conclusions HBO treatment was given within 8h after HBO treatment. The incidence of DEACMP was significantly lower than that of HBO treatment after 8h, indicating that the incidence of DEACMP is closely related to the timing of HBO treatment.