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目的 :探讨中国人缺血性脑卒中与血小板膜糖蛋白 (GP)Ⅱb/Ⅲa基因Leu33Pro多态性之间的关系。方法 :利用PCR技术和分子杂交技术对北京地区 2 94例缺血性脑卒中患者进行GPⅡb/Ⅲa基因Leu33Pro多态性的检测和分析 ,并与 2 79例北京地区的非卒中对照进行比较。结果 :缺血性脑卒中患者GPⅡb/Ⅲa基因Leu33Pro多态性的基因型频率和等位基因频率与对照组相比无明显差异。结论 :GPⅡb/Ⅲa基因Leu33Pro多态性可能不是中国人群缺血性脑卒中发病的遗传学危险因素。
Objective: To investigate the relationship between ischemic stroke and Leu33Pro polymorphism of platelet glycoprotein Ⅱb / Ⅲa gene in Chinese. Methods: Polymerase chain reaction (PCR) and molecular hybridization (PCR) were used to detect and analyze the Leu33Pro polymorphism of GPⅡb / Ⅲa in 2 94 ischemic stroke patients in Beijing and compared with non-stroke control in 2 79 Beijing patients. Results: The genotype frequency and allele frequency of Leu33Pro polymorphism of GPⅡb / Ⅲa gene in ischemic stroke patients were not significantly different from those in control group. Conclusion: The Leu33Pro polymorphism of GPⅡb / Ⅲa gene may not be a genetic risk factor for ischemic stroke in Chinese population.