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节律是生物生命活动中的基本性质,人体的正常生理活动也存在着广泛的节律性。它不仅表现在一昼夜,有时也表现在一周、一月,或一季、一年中。药物的吸收,分布、代谢、排泄和交互作用也与此息息相关,所以,用药方法不能千篇一律。如何选择在用药时间上的最佳方案,是一个值得研究的问题。对人体生理昼夜节律(俗称生物钟)的研究,大约有150年的历史,但是真正取得进展,还是近20年来的事。1960年在美国冷泉港开过一次国际性的人体生物钟专题讨论会,当时有来自各国的140名科学家参加,但总共只有几十篇论文。到1967年,这方面的论文已经达到数千篇,1973年出版了《国际时辰生物学杂志》和《时辰生物学》月刊,同年还出版了《国际时辰药理学杂志》。
Rhythm is the basic nature of biological life activities, the body’s normal physiological activities also exist a wide range of rhythm. It is not only manifested in a day and night, sometimes in a week, January, or a quarter, a year. Drug absorption, distribution, metabolism, excretion and interaction are also closely related to this, therefore, medication methods can not be stereotyped. How to choose the best solution in the medication time is a problem worth studying. About human circadian rhythm (commonly known as the biological clock) research, about 150 years of history, but the real progress, or nearly 20 years. In 1960, an international human body clock discussion was held in Cold Spring Harbor, USA. At that time, there were 140 scientists from all over the world, but only a few dozen papers in total. By 1967, the number of papers in this field had reached several thousand. In 1973, the monthly “International Time Biology” and “Time Biology” were published. In the same year, “International Journal of Time Pharmacology” was published.