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肝移植患者中艰难梭状芽孢杆菌感染(CDI)发生率为3%~7%,相关流行病学、危险因素及转归分析尚不多见。来自美国底特律的一项2000—2010年队列研究,观察了970例肝移植受者,腹泻且粪便艰难梭状芽孢杆菌阳性者确诊为CDI。采集患者的基本信息、伴发疾病、住院时间、CDI严重程度、复发率(<12周)及病死率,Cox比例风险模型分析CDI的危险因素,全部患者CDI发生率为18.9%。术后1年
The prevalence of Clostridium difficile (CDI) in liver transplant recipients is 3% to 7%. Relevant epidemiological, risk factors and outcome measures are rare. A 2000-2010 cohort study from Detroit, USA, observed 970 liver transplant recipients who were diagnosed as CDI with diarrhea and stool positive Clostridium difficile. The basic information of patients, companion disease, length of stay, severity of CDI, relapse rate (<12 weeks) and mortality were collected. The risk factors of CDI were analyzed by Cox proportional hazard model. The incidence of CDI in all patients was 18.9%. 1 year after surgery