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目的探讨人乳头瘤病毒(HPV)基因亚型检测,在宫颈病变筛查中的意义。方法选择2008年7月1日至12月31日,在台州医院宫颈疾病门诊要求进行宫颈病变筛查的病人,检测HPV-DNA21种亚型。对检测阳性者,常规行阴道镜检查与宫颈活检。结果 3300例病人中,筛查出HPV阳性者990例,阳性率30%,高危型61.8%(612/990),低危型28.9%(286/990),未确定型9.3%(92/990)。990例HPV-DNA阳性者行宫颈活检报告:湿疣样改变39.4%(390/990),慢性宫颈炎21.6%(214/990),宫颈上皮内瘤变(CIN)Ⅰ级18.8%(186/990),CINⅡ13.1%(130/990),CINⅢ4.7%(46/990)),宫颈癌2.4%(24/990)。结论高危型HPV持续感染与宫颈病变密切相关,高危型HPV检测可进一步浓缩高风险人群,使筛查更加有针对性,而感染HPV不等同于患宫颈癌。
Objective To explore the significance of detection of human papillomavirus (HPV) genotypes in screening cervical lesions. Methods From July 1, 2008 to December 31, 2008, 21 subtypes of HPV-DNA were detected in cervical disease screening patients in Taizhou Hospital. Positive tests, routine colposcopy and cervical biopsy. Results A total of 990 HPV-positive cases were screened out in 3300 patients, the positive rate was 30%, the high-risk type was 61.8% (612/990), the low-risk type was 28.9% (286/990) and the unidentified type was 9.3% (92/990) ). Cervical biopsies from 990 HPV-DNA positive patients reported 39.4% (390/990) of genital warts, 21.6% (214/990) of chronic cervicitis and 18.8% (186/990) of grade 1 cervical intraepithelial neoplasia (CIN) ), CINⅡ13.1% (130/990), CINⅢ4.7% (46/990)), cervical cancer 2.4% (24/990). Conclusions High-risk HPV infection is closely related to cervical lesions. High-risk HPV testing can further concentrate the high-risk population so that screening can be more targeted. However, HPV infection is not the same as cervical cancer.