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目的探讨胰岛素-胰岛素样生长因子(IGF)代谢轴在胎儿宫内生长发育中的作用。方法连续收集266名单胎足月新生儿基本资料,采用放免法检测脐血胰岛素和IGF水平。结果 (1)脐血胰岛素水平与出生体重、BMI、身长和胎盘重量均呈正相关(P<0.01)。(2)脐血IGF水平与出生体重、BMI、身长和胎盘重量均呈正相关(P<0.01)。(3)脐血胰岛素水平和IGF水平呈显著正相关(P<0.01)。结论脐血胰岛素、IGF水平可作为评价胎儿宫内生长发育情况的参考指标。
Objective To investigate the role of insulin-insulin-like growth factor (IGF) axis in intrauterine growth and development. Methods A total of 266 infants with singleton fetus and full-term newborns were collected continuously. The levels of insulin and IGF in cord blood were detected by radioimmunoassay. Results (1) There was a positive correlation between cord blood insulin level and birth weight, BMI, body weight and placenta weight (P <0.01). (2) There was a positive correlation between cord blood IGF level and birth weight, BMI, body length and placenta weight (P <0.01). (3) There was a significant positive correlation between cord blood insulin level and IGF level (P <0.01). Conclusion Umbilical cord blood insulin and IGF levels can be used as a reference index to evaluate the intrauterine growth and development.