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本文应用放射免疫法测定营养性佝偻病患儿活动期及经维生素D和钙剂治疗后恢复期血清I型胶原羧基端吡啶啉交联末端肽 (ICTP)水平。结果显示 30例营养性佝偻病活动期血清ICTP为 19.81± 6 .5 0 μg/L,而健康对照组为12 .0 7± 2 .79μg/L,两者具有显著性差异 (t=5 .997,P <0 .0 0 1)。 12例营养性佝偻病活动期及恢复期血清ICTP水平比较具有显著性差异 (t=3 .5 72 ,P <0 .0 1)。表明血清ICTP水平可作为营养性佝偻病活动期诊断及治疗后疗效评价指标之一。
In this paper, radioimmunoassay was used to determine the serum level of type I collagen carboxyterminal pyridioline cross-linked terminal peptide (ICTP) in patients with nutritional rickets and the recovery phase after treatment with vitamin D and calcium. The results showed that 30 patients with active rickets active serum ICTP 19.81 ± 6.50 μg / L, while the healthy control group was 12 .0 7 ± 2.79μg / L, both with significant differences (t = 5.997 , P <0 0 0 1). There were significant differences in serum ICTP levels between active rickets and convalescent trophoblast in 12 cases (t = 3.572, P <0.01). Serum ICTP levels can be used as nutritional rickets in the diagnosis and treatment of active disease after the evaluation of one of the indicators.