O~6-METHYLGUANINE-DNA METHYLTRANSFERASE AND HUMAN CANCER CHEMOTHERAPY

• 作 者: 章扬培 王德文 陈月能 吴英 徐惠英 范国才 白晓彬 王晓明 李洁珣 朱力
• 机 构: Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, PRC,Institute
• 出 处: Science in China,Ser.B
• 发表日期: 1991年06期
• 关键词: DNA cured methy suppressed probably nude quickly killed neuroblastoma chemothera

Two kinds of human tumor cell strains having different activity of O~6-methylguanine-DNA methyltransferase (O~6-MT) were transplanted into nude mice. Then the mice were inject-ed intraperitoneally with bifunctional alkylating agent 1--(4--amino--2-methyl--5--pyrimidinyl)methy1-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU). The tumors with low O~6-MTactivity were quickly suppressed or cured. The result suggests that some tumors, if previ-sionally determined with low O~6-MT activity, might be efficiently cured by treatment withACNU. This probably opens a new way for human cancer chemotherapy.

Two kinds of human tumor cell strains with different activity of O ~ 6-methylguanine-DNA methyltransferase (O ~ 6-MT) were transplanted into nude mice. Then the mice were injected- ed intraperitoneally with bifunctional alkylating agent 1 - (4- The tumors with low O ~ 6-MT activity were rapidly suppressed or cured. The result suggests that some tumors, if previ-sionally determined with low O ~ 6-MT activity, might be fast cured by treatment with ACNU. This probably opens a new way for human cancer chemotherapy.