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目的 探讨血清肿瘤坏死因子(TNF-α)与各类型脑梗死的关系及其对预后的影响。方法 采用ELISA法检测52例脑梗死病人血清TNF-α的含量。结果 脑梗死组明显高于正常对照组(P<0.001),而脑梗死急性期又较恢复期明显增高(P<0.01),大小梗死组之间也有明显差异(P<0.05)。但单梗死组与多梗死组之间则无明显差异(P>0.05)。结论 TNF-α参与了脑梗死的急性病理过程,监测TNF-α有助于临床上对脑梗死病人病情、治疗及预后的判断。
Objective To investigate the relationship between serum tumor necrosis factor (TNF-α) and various types of cerebral infarction and its prognosis. Methods The levels of serum TNF-α in 52 patients with cerebral infarction were detected by ELISA. Results The cerebral infarction group was significantly higher than that of the normal control group (P <0.001), while the acute cerebral infarction group was significantly higher than that of the recovery group (P <0.01). There was also significant difference between the infarct size group and the infarct group (P <0.05). However, there was no significant difference between single infarction group and multiple infarction group (P> 0.05). Conclusion TNF-α is involved in the acute pathological process of cerebral infarction. Monitoring TNF-α may help to judge the condition, treatment and prognosis of patients with cerebral infarction clinically.