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胚胎干细胞(embryonic stem cell,ES细胞)是指由胚胎内细胞团(innercellmass,ICM)细胞经体外抑制培养而筛选得到的细胞,具有发育上的全能性.近两年在ES细胞诱导分化方面的研究取得了一些突破性的进展,其中,ES细胞向生殖细胞分化(2003年)以及首次克隆成功人ES细胞(2004年)先后被评为《科学》杂志当年度十大科学进展之一;另外,维持ES细胞不分化状态的关键基因(Nanog)及相关化合物(BIO)的发现,其自身分化状态调控机理的深入研究,以及向不同方向诱导分化和应用等的研究成果,同样受人关注.
Embryonic stem cells (ES cells) are cells that have been selected by inner-cell inhibition (ICM) cells in vitro and have developmental pluripotency. In the past two years, ES cell differentiation Some breakthroughs have been made. Among them, ES cell differentiation to germ cells (2003) and first cloning of human ES cells (2004) have been rated as one of the ten major scientific developments of the year by Science. In addition, (Nanog) and related compounds (BIO) that maintain the status of ES cell differentiation, in-depth study on the regulation mechanism of its own differentiation state, as well as the research results of inducing differentiation and application in different directions, are also of concern.