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目的探讨EDTA-K2抗凝导致血小板假性减少症(EDTA-PTCP)的特点及原因分析。方法对本院2010~2011年间6例EDTA.K2抗凝剂所致血小板减少症的患者用不同抗凝剂检测,手工计数及血涂片瑞一姬姆萨染色法观察血小板形态的情况,结果 EDTA-K2抗凝剂测检血小板数(x±s)为(18.8±10)×10~9/L,换用3.8%枸橼酸钠法,显微镜手工计数法血小板数分别为(138.7±21)×10~9/L,(154.8±36)×10~9/L,与EDTA-K2抗凝法比较,P值均<0.01。结论 EDTA-K2抗凝血导致血小板假性减少症的发病率极低,隐蔽性强,极易误诊,对于临床上无出血倾向的血小板减少患者应排除EDTA-PTCP的可能。
Objective To investigate the characteristics and causes of EDTA-K2-induced platelet hypopigmentation (EDTA-PTCP). Methods Six patients with thrombocytopenia caused by EDTA.K2 anticoagulant in our hospital from 2010 to 2011 were detected with different anticoagulants, EDTA-K2 anticoagulant test platelet count (x ± s) was (18.8 ± 10) × 10 ~ 9 / L, replaced by 3.8% sodium citrate method, the number of manual counting microscope platelets were (138.7 ± 21 ) × 10 ~ 9 / L and (154.8 ± 36) × 10 ~ 9 / L, respectively, P value was lower than 0.01 with EDTA-K2 anticoagulation method. Conclusion The anticoagulant activity of EDTA-K2 leads to a very low incidence of pseudo-platelet hypothyroidism. It is highly concealed and easily misdiagnosed. The possibility of EDTA-PTCP should be excluded in patients with thrombocytopenia who are clinically free from bleeding.