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目的探讨冠心病患者冠状动脉病变程度对左室舒张功能的影响。方法对75例冠心病患者行心导管及超声心动图检查,根据病变狭窄程度分为轻度狭窄组、单支病变组、双支病变组及三支病变组。应用导管法测定左室血流动力学指标和心功能参数。结果常规超声心动图指标显示,仅LAD在三支病变组较轻度冠脉病变组及单支血管病变组显著增加。左心导管测定结果显示,轻度狭窄组的时间常数T低于其他各组,舒张早期1/3充盈量及充盈分数在冠状动脉显著狭窄组低于轻度狭窄组(P<0.05或0.01)。结论不同程度的冠状动脉病变对心室的舒张功能具有一定的影响,而且随着病变程度的加重影响增大。
Objective To investigate the effect of coronary artery lesion on left ventricular diastolic function in patients with coronary heart disease. Methods 75 cases of coronary heart disease patients underwent cardiac catheterization and echocardiography, according to the degree of stenosis were divided into mild stenosis group, single-vessel lesion group, double-vessel lesion group and three vessel lesion group. Left ventricular hemodynamics and cardiac function parameters were measured by catheterization. Results Conventional echocardiography showed that only LAD increased significantly in the three lesions group compared with the mild coronary artery disease group and the single vessel disease group. The results of left cardiac catheterization showed that the time constant T of mild stenosis group was lower than that of the other groups. The 1/3 filling volume and filling fraction in early diastole were lower in stenosis group than in mild stenosis group (P <0.05 or 0.01) . Conclusion Different degrees of coronary artery lesion have a certain impact on the diastolic function of ventricular, and with the severity of the lesion increased.