论文部分内容阅读
目的探讨儿童人群风疹病毒IgM抗体阳性率及与年龄、疫苗注射和自然感染的关系。方法磁微粒化学发光法风疹病毒IgM抗体试剂盒检测本院4 860例有发热、呼吸道感染或皮疹等症状的门诊和住院儿童血清样本,统计阳性和阴性检测结果的S/CO值分布范围,分析阳性结果与年龄、疫苗注射和自然感染的关系。结果共检出IgM抗体阳性样本94份,阳性率为1.9%,S/CO平均值为3.4,中位数为2.2。年龄为9个月的幼儿IgM抗体阳性数量最多,占35.1%(33/94),9个月和10个月2个年龄段的阳性数量占总阳性数量的61.7%。疫苗接种者IgM阳性S/CO值分布范围较窄,只有不到1/2的样本S/CO值>2.0,自然感染者S/CO值分布范围较宽,75%的样本S/CO值>2.0,两者差异有统计学意义(P<0.001)。结论儿童人群风疹病毒IgM抗体阳性的年龄段主要为9个月和10个月龄,疫苗注射产生的IgM抗体反应性低于自然感染者。
Objective To investigate the positive rate of rubella virus IgM antibody in children and its relationship with age, vaccination and natural infection. Methods The magnetic particle chemiluminescence method rubella virus IgM antibody kit was used to detect the serum samples from 4860 outpatients and hospitalized children with fever, respiratory tract infection or rash and so on. The distribution of S / CO values of the positive and negative test results were analyzed. Relationship between positive results and age, vaccination and natural infection. Results A total of 94 IgM positive samples were detected, the positive rate was 1.9%, the average S / CO was 3.4 and the median was 2.2. The highest number of positive IgM antibodies was found in children aged 9 months (35.1%, 33/94). The positive numbers of IgM antibodies in both age groups were 61.7% of the total positives in the two age groups of 9 months and 10 months. IgM positive S / CO values ranged from narrow to narrow, with S / CO values> 2.0 in only 1/2 of the samples, wide range of S / CO values in naturally infected individuals and S / CO values in 75% of samples> 2.0, the difference between the two was statistically significant (P <0.001). Conclusion The prevalence of rubella IgM antibodies in children is mainly at 9 months and 10 months of age. The response of IgM antibodies produced by vaccination is lower than that of naturally infected patients.