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对95例年龄小于39岁的青年人原发性肝癌（PHC）与青年慢性活动性肝炎（CAH）106例患者，进行了肝病发作史、肿瘤家族史、饮酒史、临床症状、体征及肝功能、HBVM、AFP等多方面的观察。结果提示：（1）青年人肝癌中男女之比为4：1。（2）青年肝癌组中，有肝硬化症状体征者占72．63％，OR值为17.44；慢性肝炎病史5年以上且反复发作是PHC发生的高危因素。（3）青年PHC组中，有肝癌家族史者占14．74％，明显高于青年CAH组，OR值为5.93。（4）青年PHC组中，有长期大量饮酒史者16．84％，明显高于青年CAH组6．6％，OR值为2．86。（5）本组青年肝癌就诊时，大多已属晚期，门脉癌栓发生率已达35．79％（34／95），不规则发热、腹泻消瘦、肝肿大、腹水等明显高于对照组（P＜O．01）。（6）青年PHC组中，AFP阳性率为67．37％（64／95），AFP＞400ng／ml者占43．16％，AKP、γ－GT均高于对照组（P＜0．01）。
95 cases of primary liver cancer (PHC) and 106 cases of chronic active hepatitis (CAH) in young persons under 39 years of age were examined for the history of liver attack, family history of cancer, drinking history, clinical symptoms, signs, and liver function. , HBVM, AFP and many other observations. The results suggest that: (1) The ratio of male to female in young people with liver cancer is 4:1. (2) In the young liver cancer group, there were 72.63% of patients with cirrhosis and physical signs, and the OR value was 17.44. The history of chronic hepatitis was more than 5 years and repeated attacks were the risk factors for PHC. (3) In the young PHC group, there were 14.74% of the family history of liver cancer, which was significantly higher than that of the young CAH group, with an OR of 5.93. (4) In the young PHC group, there were 16.84% of patients who had a long history of heavy drinking, which was significantly higher than the 6.6% of young CAH group, and the OR value was 2.86. (5) Most of the young liver cancer patients in this group had advanced stage. The incidence of portal vein tumor thrombosis had reached 35.79% (34/95). Irregular fever, diarrhea, weight loss, hepatomegaly, and ascites were significantly higher than the control group. Group (P < O.01). (6) In the young PHC group, the positive rate of AFP was 67.37% (64/95), AFP>400ng/ml accounted for 43.16%, AKP, γ-GT were higher than the control group (P<0.01) ).