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CD57是一种分子量为110 KD的糖蛋白,它是人类自然杀伤细胞(NK)和杀伤细胞(K)的特异性表面抗原。用它免疫小鼠产生的抗CD57单克隆抗体可特异性识别人的NK 和K 细胞表面抗原。本文应用ABC 免疫组织化学染色结合葡萄糖氧化酶DAB-硫酸镍铵显色技术研究了CD 57在人胰腺的表达和分布。结果发现,CD 57免疫反应(CD 57一IR)细胞主要分布在胰腺的内分泌部(胰岛),偶见于胰腺外分泌部的腺泡和导管上皮中。多数CD 57-IR 细胞呈典型内分泌细胞的形态特征。相邻切片法证明大多数Glu,SS,HPP 和PS 免疫反应细胞呈CD 57阳性。胰腺内神经纤维亦呈CD 57阳性。少数呈CD 57阳性的NK 和K 细胞散布在胰腺结缔组织中。本文对CD 57免疫反应性在人胰腺内分泌细胞中表达的意义进行了讨论。
CD57 is a glycoprotein with a molecular weight of 110 KD, which is a specific surface antigen of human natural killer (NK) and killer (K) cells. The anti-CD57 monoclonal antibody produced by immunizing mice can specifically recognize human NK and K cell surface antigens. In this study, ABC immunohistochemical staining combined with glucose oxidase DAB-nickel sulfate ammonium chromogenic assay CD 57 in human pancreas expression and distribution. As a result, it was found that the CD 57 -immunoreaction (CD 57-IR) cells are mainly located in the endocrine (pancreatic islets) of the pancreas and are occasionally found in the acinar and ductal epithelium of the exocrine part of the pancreas. Most CD 57-IR cells have the morphological characteristics of typical endocrine cells. Adjacent sections demonstrated that most of the Glu, SS, HPP and PS immunoreactive cells were CD 57 positive. Pancreatic nerve fibers were also CD 57 positive. A small number of CD57-positive NK and K cells are scattered in pancreatic connective tissue. The significance of CD 57 immunoreactivity in human pancreatic endocrine cells is discussed in this paper.