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新生儿坏死性小肠结肠炎(Neonatal Ne-crotizing EnteroColitis,简称NEC)是新生儿期小肠和大肠粘膜及粘膜下层的弥漫性或局灶性坏死,是由多种原因引起的综合征。Siebold 1825年首次报道本病,但至一个世纪以后才引起人们重视,目前已成为新生儿尤其是未成熟儿的主要死亡原因之一。本文复习NEC有关文献作一综述, 一、发病率:NEC的发病率,各家报道不一。Franty等报道54例,占住院婴儿的4.7％,其中未成熟儿占91％。美国哈佛大学医学院新生儿科报道未成熟儿发病率为1～10％。国内上一医儿科医院统计1978～1980年收治NEC 30例,占新生儿住院患者1.1％。以病儿集中的治疗中心发病率最高,而在一些普通产院、健康婴儿较多的婴儿室发病率较低。
Neonatal Ne-crotizing EnteroColitis (NEC) is a diffuse or focal necrosis of the small intestine, the large intestine mucosa, and the submucosa during the neonatal period and is caused by a variety of causes. Siebold first reported the disease in 1825, but it did not attract much attention until a century later. It has become one of the major causes of death in newborns, especially immature children. This review of NEC literature review, a, morbidity: incidence of NEC, various reports vary. Franty and other reports 54 cases, accounting for 4.7% of infants in hospital, of which 91% of immature children. Harvard Medical School neonatal reports the incidence of immature children is 1 to 10%. Statistics from a domestic pediatric hospital in the past 1978-1980 admitted NEC 30 cases, accounting for 1.1% of neonatal inpatients. The highest incidence of treatment centers with sick children, while in some common births, the incidence of infants with more healthy infants is lower.