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目的:运用前哨淋巴结活检对乳腺癌患者的淋巴结转移情况进行判断。方法:54例均系2006年6月—2008年12月在我院外科接受手术的乳腺癌患者,术中注射亚甲蓝定位前哨淋巴结(SLN)并活检,后行常规腋窝淋巴结清扫,术后进行病理检查。结果:本组54例乳腺癌中,检出SLN49例,检出率为90.74%(49/54)。24例SLN阳性患者中,ALND阳性16例,ALND阴性8例;25例SLN阴性患者中,ALND阳性3例,ALND阴性22例。准确率为93.88%(46/49),灵敏度为88.89%(24/27),假阴性率为11.11%(3/27)。SLN检出率与患者年龄、组织学分型无明显相关(P>0.05),与肿瘤大小、腋窝淋巴结状态显著相关(P<0.05)。结论:亚甲蓝染色法SLNB技术临床可行,前哨淋巴结活检能准确预测乳腺癌腋窝淋巴结状态。
Objective: To evaluate the lymph node metastasis in patients with breast cancer using sentinel lymph node biopsy. Methods: All 54 patients were breast cancer patients surgically treated in our hospital from June 2006 to December 2008. Intraoperative injection of methylene blue for sentinel lymph node (SLN) biopsy and routine axillary lymph node dissection, postoperative Perform pathological examination. Results: Of 54 cases of breast cancer, SLN was detected in 49 cases, the detection rate was 90.74% (49/54). Of 24 SLN-positive patients, 16 were ALND-positive and 8 were ALND-negative. Of 25 SLN-negative patients, 3 were ALND positive and 22 were ALND negative. The accuracy was 93.88% (46/49), the sensitivity was 88.89% (24/27) and the false negative rate was 11.11% (3/27). There was no significant correlation between SLN detection rate and patient’s age and histological type (P> 0.05), but significantly correlated with tumor size and axillary lymph node status (P <0.05). Conclusion: Methylene blue staining method SLNB clinical feasibility, sentinel lymph node biopsy can accurately predict breast cancer axillary lymph node status.