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目的:通过对榆林市初发2型糖尿病患者的胰岛功能进行跟踪观察,探讨初发2型糖尿病患者胰岛功能的变化特点。方法:选取榆林市1220例初发2型糖尿病患者作为观察对象,跟踪随访12个月,在就诊后的3个月、6个月及12个月时,检测全部患者的血糖水平、C-肽释放量,计算胰岛素分泌指数(HOMA-β)及胰岛素抵抗指数(HOMA-IR),观察总结患者的胰岛功能变化特点。结果:随访期间,糖尿病患者C-肽释放量持续降低,且在就诊后3个月内,C-肽释放量下降明显(P<0.05),与就诊后6个月时及12个月时比较,糖尿病患者胰岛素放量持续降低,就诊后3个月内下降最明显(P<0.05);患者胰岛素分泌指数持续降低(P<0.05),胰岛素抵抗指数持续升高(P<0.05),且与6个月时和12个月时比较,3个月时变化幅度最为显著(P<0.05)。结论:随着病程的延长,初发2型糖尿病患者胰岛功能逐渐降低,二者具有显著相关性,且3个月内患者的胰岛功能下降最为显著。
OBJECTIVE: To observe the changes of pancreatic islet function in patients with newly diagnosed type 2 diabetes mellitus by tracing the islet function of patients with newly diagnosed type 2 diabetes in Yulin. Methods: A total of 1220 newly diagnosed type 2 diabetic patients in Yulin City were selected as the observation objects. All the patients were followed up for 12 months. Blood glucose levels were measured at 3, 6 and 12 months after treatment. C-peptide (HOMA-β) and insulin resistance index (HOMA-IR) were calculated and the characteristics of pancreatic islet function were observed and summarized. Results: During follow-up, the release of C-peptide in diabetic patients continued to decrease, and the release of C-peptide decreased significantly within 3 months after treatment (P <0.05), compared with 6 and 12 months after treatment (P <0.05). The insulin secretion index decreased continuously (P <0.05) and the insulin resistance index increased continuously (P <0.05) in patients with diabetes mellitus, The changes were most significant at 3 months when compared with those at 12 months (P <0.05). CONCLUSION: With the prolongation of the course of disease, the islet function of newly diagnosed type 2 diabetic patients gradually decreases. The two have significant correlation, and the most significant decrease of pancreatic islet function in 3 months.