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硫化物的硫离子能迅速抑制线粒体内的细胞色素氧化酶,导致组织缺氧。4-二甲基氨基苯酚和对氨基苯丙酮是高铁血红蛋白形成剂,其形成的高铁血红蛋白能与硫离子结合而释放细胞色素氧化酶,从而有效地预防硫离子对细胞色素氧化酶的抑制。本文研究了4-二甲基氨基苯酚和对氨基苯丙酮伍用对小鼠和家兔分别硫化钠中毒的预防作用。实验结果表明,4-二甲基氨基本酚(60mgkg~(-1))和对氨基
Sulfide sulfide ions can rapidly inhibit mitochondrial cytochrome oxidase, leading to tissue hypoxia. 4-Dimethylaminophenol and p-aminopropiophenone are methemoglobin forming agents that form methemoglobin that binds to sulfide ions to release cytochrome oxidase, thereby effectively preventing the inhibition of cytosolic oxidase by sulfide ions. This paper studied the prophylactic effect of 4-dimethylaminophenol and p-aminopropiophenone on sodium sulfide poisoning in mice and rabbits. The experimental results show that 4-dimethylaminophenol (60mgkg -1) and para-amino group