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[目的]评价郓城县全面实施儿童乙型肝炎免疫接种的效果。[方法]2007年10～12月,在郓城县县城内抽取幼儿园、小学、初中各2所,对部分2～14岁儿童进行调查。[结果]调查3819人,完成全程以上接种(包括全程接种后进行1～2次加强免疫)乙肝疫苗的占91.10%,单纯HBsAg阳性检出率为0.84%,乙肝患病率为0.47%。全程以上接种率有随着年龄的增长而降低的趋势(P<0.01);单纯HBsAg阳性率,2～10岁、11～12岁、13～14岁分别为0.41%、1.43%、6.00%(P<0.01);乙肝患病率2～10岁为0.10%,11～14岁为1.64%(P<0.01)。全面实施乙肝免疫后与实施前出生的,完成全程以上乙肝疫苗接种者所占比例分别为91.49%、62.00%(P<0.01),单项HBsAg阳性的分别占0.63%、6.00%(P<0.01),乙肝患病率分别为0.35%、3.33%(直接概率P=1.00)。[结论]全面实施乙肝疫苗接种可以降低儿童乙肝病毒感染率与乙肝发病率。
[Objective] To evaluate the effect of full-scale hepatitis B immunization in Yuncheng County. [Method] From October to December 2007, 2 kindergartens, primary schools and junior high schools were selected in Tancheng County, and some of the children aged 2-14 were investigated. [Results] A total of 3819 people were surveyed, 91.10% completed hepatitis B vaccination (including one or two booster immunizations after the whole course of vaccination), the detection rate of HBsAg was 0.84%, and the prevalence of HBV was 0.47%. The rate of HBsAg positive was only 0.41%, 1.43%, 6.00% at the age of 2 to 10 years, the age of 11 to 12 years and the age of 13 to 14 years, respectively (P <0.01) P <0.01). The prevalence of hepatitis B was 0.10% at 2-10 years and 1.64% at 11-14 years (P <0.01). The percentages of those who were born before and after the full implementation of hepatitis B vaccination were 91.49% and 62.00% respectively (P <0.01), and those who were HBsAg positive accounted for 0.63% and 6.00% (P <0.01), respectively , Prevalence of hepatitis B were 0.35%, 3.33% (direct probability P = 1.00). [Conclusion] The full implementation of hepatitis B vaccination can reduce the incidence of hepatitis B virus infection and hepatitis B incidence in children.