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目的探讨二甲基甲酰胺(DMF)职业接触人群血液生物标志物。方法选择某皮革厂DMF职业接触人群99人为接触组,不接触DMF及其他有机溶剂的人员22人作为对照组。测定两组人群血液中N-甲基氨甲酰加合物、尿中甲基甲酰胺(NMF)、尿中巯基尿酸(AMCC)3个指标。对上述3个指标的相关性进行探讨。结果随着DMF职业接触浓度的增加,上述3个指标测定结果逐步升高。Spearman等级相关分析表明,3项指标间存在着明显的相关性(P<0.01)。结论血液中N-甲基氨甲酰加合物可作为反映DMF长期接触的标志物。
Objective To investigate the blood biomarkers of occupational exposure to dimethylformamide (DMF). Methods Totally 99 people in DMF contact group and 22 persons who did not contact with DMF and other organic solvents were selected as the control group. Three indexes of blood N-methylcarbamoyl adduct, urine methylformamide (NMF) and urinary thiouracil-uric acid (AMCC) were measured in two groups. The three indicators of the relevance of the discussion. Results With the increase of occupational exposure to DMF, the results of the above three indexes increased gradually. Spearman rank correlation analysis showed that there was a significant correlation between the three indicators (P <0.01). Conclusion The blood N-methylcarbamoyl adduct can be used as a long-term exposure to DMF markers.