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马钱子常见于中药制剂,其主要活性成分为士的宁(1)和马钱子碱(2),均为叔胺结构,难溶于水,具有强毒性,其有效剂量和中毒剂量非常接近,易发生中毒[1]。因此必须对这些中药制剂的生产设备进行严格的清洗,并且还要对其生产废水中的痕量1和2预处理,合格后才能排放。清洗及预处理后是否达到限度要求,须进行清洁验证,以有效防止可能产生的污染及交叉污染[2]。1和2的检测主要采用分光光度法[3]、薄层扫描法[4]、毛细管区带电泳法[5]、HPLC法[6]和GC法[7]等,然而其灵
Strychnos commonly found in traditional Chinese medicine preparations, the main active ingredient is strychnine (1) and brucine (2), are tertiary amine structure, insoluble in water, highly toxic, the effective dose and poisoning dose is very Proximity, prone to poisoning [1]. Therefore, we must strictly clean the production equipment of these traditional Chinese medicine preparations, and also pre-treat the trace amounts 1 and 2 in the wastewater they produce before they can be discharged. Cleaning and pre-treatment whether to meet the limit requirements, the need for cleaning validation, in order to effectively prevent possible pollution and cross-contamination [2]. Spectrophotometry [3], TLC [4], capillary zone electrophoresis [5], HPLC [6] and GC [7] were used for the detection of 1 and 2,