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目的:优化迟发性面瘫的建模方法,并对药物的神经保护作用进行观察。方法:家兔48只共96侧面神经,分A、B、C、D 4个实验组,以一侧面神经进行实验处理,另一侧为自身对照。A组:直视下钳夹损伤桥池段面神经;B组:直视下向桥小脑角注射动脉血,以诱导血管痉挛;C组:处理因素=A组+B组;D组:在C组基础上,应用药物(强的松+丹参+维生素B1+维生素B12)干预。观察家兔面瘫,并做面神经病理切片,比较各组间迟发性面瘫发生率、面瘫持续时间及预后。结果:面瘫发生情况:A组6只家兔(6/11,54.5%)出现迟发性面瘫;平均面瘫持续时间为13.2天。B组有2只(2/12,16.7%)出现迟发性面瘫,平均持续8天。C组6只(6/12,50%)家兔出现迟发性面瘫,平均持续14.3天。D组4只(4/12,33.33%)出现迟发性面瘫,平均持续6天。所有自身对照侧均无面瘫发生。病理:各组均见神经纤维水肿;A、C两组呈高度水肿改变,神经束周围结构紊乱;B组见神经内血管细小,而水肿较A、C两组轻微;D组呈轻度水肿改变。结论:C组出现迟发性面瘫几率高,是较好的模型;联合应用强的松、丹参、维生素B1、维生素B12虽不能防止迟发性面瘫发生,但可使迟发性面瘫病程明显缩短。
Objective: To optimize the modeling method of delayed facial paralysis and to observe the neuroprotective effect of the drug. Methods: A total of 96 rabbits were divided into four groups (A, B, C and D). 48 rabbits were experimentally treated with one side facial nerve and the other side was their own control. In group A, the facial nerve in the bridge segment was injured under direct vision; in group B, arterial blood was injected into the bridge cerebellopontus under direct vision to induce vasospasm; group C: treatment factor = group A + B; group D: Group based on the application of drugs (prednisone + Salvia + Vitamin B1 + Vitamin B12) intervention. Facial paralysis was observed in rabbits and facial nerve pathology was performed. The incidence of delayed facial palsy, duration of facial paralysis and prognosis were compared between groups. Results: The incidence of facial paralysis: A group of 6 rabbits (6 / 11,54.5%) showed delayed facial paralysis; average duration of facial paralysis was 13.2 days. B group had 2 (2/12, 16.7%) delayed facial paralysis, an average of 8 days. Delayed facial paralysis occurred in 6 (6 / 12,50%) rabbits in group C, averaging 14.3 days. D group 4 (4 / 12,33.33%) showed delayed facial paralysis, an average of 6 days. All self-control side without facial paralysis occurred. Pathology: nerve fibers in each group were edema; A, C two groups showed a high degree of edema, nerve bundle structure around the disorder; B group, see intracranial blood vessels small, and edema than A, C two groups slightly; D group was mild edema change. CONCLUSION: C is a good model for the occurrence of delayed facial paralysis. Although combination of prednisone, salvia miltiorrhiza, vitamin B1 and vitamin B12 can not prevent the occurrence of delayed facial paralysis, the course of delayed facial paralysis can be significantly shortened .