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目的观察强肝糖浆联合异甘草酸镁对药物性肝炎的临床治疗效果。方法随机将2013年3月—2016年3月在本院治疗的98例药物性肝炎患者按照随机数字表法分为两组,每组49例。对照组在采用常规保肝和支持治疗基础上,给予异甘草酸镁治疗;治疗组在对照组的治疗的基础上每天加服强肝糖浆。比较两组患者的临床治疗效果、肝功能及对药物的不良反应。结果治疗组总有效率为95.92%,对照组总有效率为83.67%,二者对比有显著性差异(P<0.05),两组肝功能指标丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)和总胆红素(TBIL)水平在给药治疗后与治疗前相比均有显著性降低(P<0.05),治疗后,与对照组比较,治疗组肝功能指标AST显著降低(P<0.05)。结论强肝糖浆联合异甘草酸镁治疗药物性肝炎临床疗效显著,可显著改善患者肝功能,无明显不良反应,值得临床推广应用。
Objective To observe the clinical effect of Qianggan syrup combined with isoglycyrrhizinate on drug-induced hepatitis. Methods A total of 98 patients with drug-induced hepatitis who were treated in our hospital from March 2013 to March 2016 were randomly divided into two groups (n = 49 in each group). The control group was given magnesium isoglycyrrhizinate on the basis of routine hepatoprotection and supportive therapy. The treatment group was given strong hepatic syrup on a daily basis based on the treatment of the control group. The clinical effects, liver function and adverse reactions to the drugs in both groups were compared. Results The total effective rate was 95.92% in the treatment group and 83.67% in the control group, and there was significant difference between the two groups (P <0.05). The liver function indexes of alanine aminotransferase (ALT), aspartate Compared with the control group, the levels of AST and TBIL were significantly decreased after treatment (P <0.05), and after treatment, compared with the control group, the liver function of the treatment group AST was significantly lower (P <0.05). Conclusion Strong liver syrup combined with magnesium isoglycyrrhizinate in the treatment of drug-induced hepatitis has significant clinical curative effect, can significantly improve liver function in patients without obvious adverse reactions, and is worthy of clinical application.