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1,8-双-(二氯乙酰胺基)-辛烷(I,WIN 18446)具有抗生精作用本所合成的该药进行动物试验,证明有效。国内曾作为男用避孕药进行临床试用,效果也好;但剂量大,起效慢,又不可饮酒,因此不宜推广应用。具有二氯乙酰胺基的化合物如氯霉素(Ⅱa)影响鸡胚发育,甲砜霉素(Ⅱb)影响大白鼠怀孕,克痢酰胺(Ⅲ)和N,N′-二烷基-N,N′-双-(二氯乙酰)-1,
1,8-bis- (dichloroacetamido) -octane (I, WIN 18446) has anti-spermatogenic activity The drug synthesized in this study was tested in animals and proved to be effective. Domestic as a male contraceptives for clinical trials, the effect is good; but a large dose, slow onset, they can not drink alcohol, it is not appropriate to promote the application. Compounds with dichloroacetamido groups such as chloramphenicol (IIa) affect chicken embryo development, thiamphenicol (IIb) affects pregnant rats, cilomilamide (III) and N, N’-dialkyl- N’-bis- (dichloroacetyl) -1,