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本文用放射免疫方法测定45例流行性出血热(EHF)各期病人与15例健康成人血浆内皮素(ET)含量。结果表明,除 V 期外 EHF 各期病人血浆 ET 含量均较显著高于正常人(P<0.01)。同时观察了各病期中(除Ⅰ期)ET 与血尿素氮、血肌酐的关系,有显著相关性。EHF 最基本的病理变化是全身小血管损害,可能是 ET 升高的主要机制。
In this paper, 45 patients with epidemic hemorrhagic fever (EHF) patients and 15 healthy adults plasma endothelin (ET) levels were determined by radioimmunoassay. The results showed that the plasma ET levels in all EHF patients except V were significantly higher than those in normal controls (P <0.01). In the meantime, we observed the relationship between ET and blood urea nitrogen and serum creatinine in each phase (except phase Ⅰ), and had a significant correlation. EHF is the most basic pathological changes in systemic small vessel damage, may be the main mechanism of ET increased.