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目的 探讨 1、 2型糖尿病患者血脂和血清酶的变化特点。方法 对 2 2例 1型糖尿病患者、 1 34例2型糖尿病患者和 5 2例非糖尿病患者对照进行了空腹 1 2小时后血糖 (GLU)、血清尿素氮 (BUN)、肌酐 (CR)、尿酸 (UA)、谷丙转氨酶 (ALT)、谷草转氨酶 (AST)、乳酸脱氢酶 (LDH)、磷酸肌酸激酶 (CK)、α 羟丁酸脱氢酶(HBDH)、总胆固醇 (CH)、甘油三酯 (TG)、高密度脂蛋白胆固醇 (HDL C)、低密度脂蛋白胆固醇 (LDL C)、载脂蛋白A (ApoA)、载脂蛋白B (ApoB)等指标的测定。 结果 1型糖尿病组与对照组比较 ,GLU、BUN、CR、ALT、HBDH、CH、ApoB高于对照组 (P <0 0 5或 0 0 1 ) ,HDL C、ApoA低于对照组 (P <0 0 5 )。 2型糖尿病组与对照组比较 ,GLU、BUN、CR、ALT、AST、LDH、CK、HBDH、LDL C、ApoB高于对照组 (P <0 0 5或 <0 0 1 ) ,HDL C、ApoA低于对照组 (P <0 0 1 )。 1型糖尿病组与 2型糖尿病组比较 ,GLU、BUN、HDL C等指标 1型糖尿病组高于 2型糖尿病组 (P <0 0 1 )。结论 1型糖尿病的血糖水平高于 2型糖尿病。 1、 2型糖尿病人群均存在脂代谢的异常 ,血清心肌酶谱的变化和心、肝、肾等主要脏器受损 ,但其程度有差异 ,2型糖尿病伴发冠心病的危险性高于 1型糖尿病。对糖尿病患者的治疗关注脂代谢紊?
Objective To investigate the changes of serum lipids and serum enzymes in type 1 and type 2 diabetic patients. Methods Blood glucose (GLU), serum urea nitrogen (BUN), creatinine (CR) and uric acid were determined in 22 patients with type 1 diabetes, 134 with type 2 diabetes and 52 without diabetes. (UA), ALT, AST, LDH, CK, HBDH, total cholesterol (CH), total cholesterol Triglyceride (TG), high density lipoprotein cholesterol (HDL C), low density lipoprotein cholesterol (LDL C), apolipoprotein A (ApoA), apolipoprotein B (ApoB) and other indicators of the determination. Results Compared with the control group, the levels of GLU, BUN, CR, ALT, HBDH, CH and ApoB in type 1 diabetic group were significantly higher than those in control group (P <0.05 or 0.01) 0 0 5). The levels of GLU, BUN, CR, ALT, AST, LDH, CK, HBDH, LDL C and ApoB in type 2 diabetes mellitus group were higher than those in control group (P <0.05 or <0.01) Lower than the control group (P <0.01). Compared with type 2 diabetes mellitus, type 1 diabetes mellitus (GLU, BUN, HDL C, etc.) was significantly higher in type 1 diabetic patients than in type 2 diabetic patients (P <0.01). Conclusion Type 1 diabetes has higher blood glucose levels than type 2 diabetes mellitus. 1 and 2 diabetes mellitus patients had abnormal lipid metabolism, changes in serum myocardial enzymes and heart, liver, kidney and other major organ damage, but the extent of difference, type 2 diabetes with coronary heart disease risk is higher than Type 1 diabetes. Concerned about lipid metabolism in the treatment of diabetic patients?