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目的 观察硫酸镁联合立其丁治疗充血性心力衰竭 (CHF)的临床疗效。方法 将 72例CHF患者随机分为治疗组和对照组各 36例。对照组给予常规治疗。治疗组在常规治疗的基础上 ,加用 2 5 %硫酸镁 1 0ml、立其丁 1 0mg于 5 %葡萄糖注射液 2 5 0ml中静脉滴注 ,每日 1次 ,2周为一疗程。结果 两组治疗后心功能均有改善 ,治疗组与对照组的总有效率分别为 80 %和 6 2 %。治疗组治疗前后的心率、血压、血镁含量、左心室舒张未期直径(LVDd)、左心室射血分数 (LVEF)比较均有统计学差异 ,P <0 0 1 ,而对照组只有心率、LVEF与治疗前比较有统计学差异 ,分别为P <0 0 1 ,P <0 0 5。结论 硫酸镁联合立其丁对CHF确有良好治疗作用 ,且未发现有明显的不良反应 ,值得临床推广应用。
Objective To observe the clinical efficacy of magnesium sulfate combined with Ritrenin in the treatment of congestive heart failure (CHF). Methods 72 patients with CHF were randomly divided into treatment group and control group, 36 cases each. The control group was given routine treatment. On the basis of routine treatment, the treatment group was treated with 10% 25% magnesium sulfate and 10 mg Lizhi Ding in 250ml 5% dextrose injection intravenously once daily for 2 weeks. Results The cardiac function of both groups improved after treatment. The total effective rates of the treatment group and the control group were 80% and 62% respectively. The heart rate, blood pressure, blood magnesium level, LVDd and LVEF in the treatment group before and after treatment were all statistically significant (P <0.01), while those in the control group were only heart rate, There was significant difference between LVEF and before treatment, P <0 01, P 0 05 respectively. Conclusion Magnesium sulfate combined with Lizhi Ding has a good therapeutic effect on CHF, and no obvious adverse reactions were found, which is worthy of clinical application.