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目的通过对北京市密云地区腹泻患者粪便标本监测结果的分析,了解腹泻致病菌的型别分布及耐药特征,为细菌性腹泻的治疗提供科学依据。方法 2014年1月-2016年9月,以密云区医院和密云中医院为哨点医院,收集腹泻患者粪便标本,分析腹泻致病菌的型别分布及耐药特征。结果共监测腹泻患者1 400例,分离致病菌123株,分离阳性率为8.8%,其中沙门菌56株,致泻性大肠埃希菌29株,副溶血性弧菌38株,未检出志贺菌。仅3株副溶血性弧菌对氨苄西林耐药。沙门菌和致泻性大肠埃希菌对喹诺酮类、四环素类耐药率较高。41.1%的沙门菌和44.8%的致泻性大肠埃希菌为多重耐药,这2种菌有耐药模式重叠情况。结论沙门菌和致泻性大肠埃希菌耐药情况比副溶血性弧菌严重,应加强致病菌耐药趋势的主动监测。
Objective To investigate the type distribution and drug resistance of diarrhea pathogens in diarrhea patients in Miyun area of Beijing and to provide scientific basis for the treatment of bacterial diarrhea. Methods From January 2014 to September 2016, Miyun District Hospital and Miyun Chinese Medicine Hospital were selected as sentinel hospitals. Stool samples of diarrhea patients were collected to analyze the type distribution and drug resistance of pathogens causing diarrhea. Results A total of 1 400 cases of diarrhea were detected. 123 pathogens were isolated and the positive rate was 8.8%. Among them, 56 strains of Salmonella, 29 strains of diarrheal Escherichia coli and 38 strains of Vibrio parahaemolyticus were not detected Shigella. Only three strains of Vibrio parahaemolyticus were resistant to ampicillin. Salmonella and diarrheal Escherichia coli quinolones, tetracycline resistance rate is higher. 41.1% of Salmonella and 44.8% of diarrheal Escherichia coli were multi-drug resistant, and the two strains had overlapping patterns of drug resistance. Conclusions Salmonella and diarrheal Escherichia coli are more resistant than Vibrio parahaemolyticus, and the active surveillance of pathogenic bacteria should be strengthened.